Keywords: infection diabetic foot ulcers multidrug-resistance bacteria antibiotic anaerobic culture samples. A relatively low proportion of the aetiological agents were anaerobic bacteria Factors associated with presence of multidrug-resistant bacteria were peripheral neuropathy (adjusted odds ratio = 4.05, p = 0.04) and duration of foot infection of more than 1 month (AOR = 7.63, p = 0.02ĬONCLUSION: Multidrug-resistant facultative anaerobic bacteria are overrepresented as agents of IDFU. Only 4 (3.1%) GNB produced carbapenemases encoded predominantly by bla VIM. aureus and GNB producing extended-spectrum β -lactamases, mainly of the CTX-M variety. Seventy-four IDFUs (80%) were infected by multidrug-resistant bacteria, predominantly methicillin-resistant S. (7 3.2%) and Peptostreptococcus anaerobius (6 2.8%). The most common anaerobes were Bacteroides spp. The top five facultative anaerobic bacteria isolated were: Staphylococcus aureus (34 15.6%), Escherichia coli (23 10.6%), Pseudomonas aeruginosa (20 9.2%), Klebsiella pneumoniae (19 8.7%) and Citrobacter spp. RESULTS: There were 218 microorganisms isolated from 93 IDFUs, comprising 129 (59.2%) Gram-negative bacilli (GNB), 59 (27.1%) Gram-positive cocci and 29 (13.3%) anaerobic bacteria. Specific resistance genes were detected by polymerase chain reaction Bacterial identification, antibiotic susceptibility testing and phenotypic detection of extended-spectrum beta-lactamase and carbapenemase production were done by established protocols. METHODS: Isolates were cultured from tissue biopsies or aspirates collected from patients with IDFU. OBJECTIVE: The study investigated the aetiology and antibacterial drug resistance burden of IDFU in tertiary hospitals in Osun state, Nigeria, between July 2016 and April 2017 Very few published data on IDFU exist in most West African countries IVDepartment of Medical Microbiology and Parasitology, Faculty of Basic Medical Science, Obafemi Awolowo University, Ile-Ife, NigeriaīACKGROUND: Infected diabetic foot ulcer (IDFU) is a public health issue and the leading cause of non-traumatic limb amputation. IIIDepartment of Microbiology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait IIDepartment of Medicine, Faculty of Clinical Science, Obafemi Awolowo University, Ile-Ife, Nigeria

IDepartment of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals, Ile-Ife, Nigeria

Adeyemo I Babatope Kolawole II Vincent O. Multicentre study of the burden of multidrug-resistant bacteria in the aetiology of infected diabetic foot ulcersĪdeyemi T.

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